1) Use is forbidden in pregnant women and children under 1 year of age. Use with caution in the elderly above 75 years of age. 2) Use is forbidden in those with a history of allergic or severe adverse reactions to this drug or preparations containing andrographolide total sulfonate. 3) Enhanced monitoring is recommended in patients using XYPI for the first time; pay close attention to reactions during administration, especially if discovering abnormalities within 30 min of administration. Stop administration immediately and take active rescue measures. 4) When used in combination with other injections, XYPI should be administered first. Other injections can be infused after flushing or replacing the infusion tube.