Immune-regulation Reduces levels of B lymphocytes, CD8+ proportion, IL-1α, IL-1β, IL-2, IgM, IgG, etc., reduces quality of thymus, spleen and lung of pneumonia mice, and increase CD4+/CD8+ and NK cell proportion (Ma et al., 2019). AECOPD Reduces levels of IL-8, TNF-α, CRP and PCT (Yu H. X. et al., 2020) and increases arterial blood gas PaO2 (Wang, 2015).