Physicians should pay attention to the reasonable application of CPMs to treat COVID-19. Severe patients are prone to septic shock, and liver and kidney dysfunction. In patients with related underlying diseases, drug metabolism and clearance are reduced. Treatment options: hepato-renal toxic drugs should be avoided to reduce the risk of drug accumulation and poisoning. For example, AGNHP contains cinnabar and realgar, and should not be taken for a long time. People with liver and kidney dysfunction should use with caution. TRQI should be carefully selected because it aggravates liver and kidney function; LHQWC and JHQGG contain ephedrae herba (Mahuang), and doctors need to monitor patients’ blood pressure, heart condition and combined use of antihypertensive drugs. In clinical application of XBJI, SFI and other traditional Chinese medicine injections, attention should be paid to the choice of solvent and the interval between infusions with other drugs. As is well known, clinicians use CPMs under the guidance of the theory of TCM. Foreign doctors and patients wishing to use CPMs to treat COVID-19 should exercise caution, especially in countries where they may be used incorrectly without the knowledge of TCM theory.