Nonstandard Abbreviations and Acronyms ACE-2angiotensin-converting enzyme 2 ARDSacute respiratory distress syndrome COVID-19coronavirus disease 2019 CRPC-reactive protein DPP-4dipeptidyl peptidase 4 GPglycoprotein HIFshypoxia-inducible transcription factors HMGBhigh mobility group box protein HSV-1herpes simplex virus 1 ICAM-1intercellular adhesion molecule 1 IFNinterferon ILinterleukin MCP-1monocyte chemoattractant protein 1 MERS-CoVMiddle Eastern respiratory syndrome coronavirus MIPmacrophage inflammatory protein MPOmyeloperoxidase NETsneutrophil extracellular traps NF-κBnuclear factor κ light-chain-enhancer of activated B cells PAFplatelet-activating factor PAR-4protease-activated receptor 4 PRRpattern recognition receptors PSGL-1P-selectin glycoprotein ligand 1 RANTESregulated on activation, normal T-cell expressed and secreted RBDreceptor-binding domain SARS-CoV-2severe acute respiratory syndrome coronavirus 2 TFPItissue factor pathway inhibitor TLRToll-like receptors TMPRSS-2transmembrane protease serine 2 tPAtissue-type plasminogen activator VTEvenous thromboembolism VWFvon Willebrand Factor * J.D.M. and H.S. contributed equally to this article. For Sources of Funding and Disclosures, see page 584.