leagues who developed NPs coated with mercapto-1-undecanesulfonate (MUS) ligands (Au-MUS NPs). The long aliphatic and flexible linkers provide stronger associations with the viral particles compared to Au-MES NPs, leading to local distortions and eventually inducing a global deformation and breaking of the capsid that inactivates its contagion irreversibly (Figure 8).90 These Au-MUS NPs were tested against different HSPG-dependent viruses, showing a high viricidal activity over HSV, HPV, and RSV (Figure 9A). Furthermore, the activity of t