Hard nanomaterials (HNMs) have been extensively studied for many types of applications including drug delivery, bioimaging, and biosensing.3−5 The use of nanomaterials in biomedical research is highly developed, reaching in some cases clinical approval.6 Despite that, nanomaterials have been mainly developed for cancer therapy, while scarce attention has been spent on their application in viral infections.7 The continuous virology research has more and more increased into viral replication machinery, allowing the preparation and rationalization of more sophisticated vaccine formulations and viral inhibitors. The use of HNMs may be one of the keys to provide more effective biomedical agents with a wide spectrum of activity in viral pandemics.8