size (nm) active concentration mechanism of action ref HIV-1 spherical 1–10 25 μg/mL interaction with gp120 (11) HIV-1 IIIB – 30–50 440 μg/mL interaction with gp120 (19) HSV-1, HSV-2, and HPIV-3 – 20–50 not available possible interaction directly with the viral envelope or its protein (20) Adenovirus type 3 spherical 5–18 25 μg/mL direct destruction of virus particles and DNA structure (15) H1N1 influenza A v