virus shape size (nm) active concentration mechanism of action ref HIV-1 spherical 1–10 25 μg/mL interaction with gp120 (11) HIV-1 IIIB – 30–50 440 μg/mL interaction with gp120 (19) HSV-1, HSV-2, and HPIV-3 – 20–50 not available possible interaction directly with the viral envelope or its protein (20) Adenovirus type 3 spherical 5–18 25 μg/mL direct destruction of virus particles and DNA structure (15) H1N1 influenza A virus spherical 5–20 12.5 μg/mL inhibition of respiratory enzymes and electron transport components and interference with DNA function (21) HBV spherical 10–50 5 μM interaction with double-stranded DNA and/or binding with viral particles (16) PPRV spherical 5–30 11.1 μg/mL interaction with virus surface and core (12) Vaccinia virus spherical 25 not available preventing viral entry into host cells (13) Monkey pox virus (MPV) – 10–80 12.5 μg/mL blocking virus-host cell binding and penetration (22) Tacaribe virus (TCRV) – 5–10 25 μg/mL inactivation of virus particles before entry (23) Poliovirus spherical 4–9 3.1 ppm preventing viral particles from binding to the receptors of RD cells (24) TGEV spherical <20 12.5 μg/mL direct interaction with TGEV surface protein, such as TGEV S glycoprotein (18) linear 60000–80000 linear 20000–30000