PMC:7373848 / 20555-21072 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T3","span":{"begin":501,"end":511},"obj":"https://glytoucan.org/Structures/Glycans/G00017MO"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T361","span":{"begin":14,"end":22},"obj":"Body_part"},{"id":"T362","span":{"begin":45,"end":61},"obj":"Body_part"},{"id":"T363","span":{"begin":57,"end":61},"obj":"Body_part"},{"id":"T364","span":{"begin":249,"end":265},"obj":"Body_part"},{"id":"T365","span":{"begin":261,"end":265},"obj":"Body_part"},{"id":"T366","span":{"begin":277,"end":287},"obj":"Body_part"},{"id":"T367","span":{"begin":368,"end":376},"obj":"Body_part"},{"id":"T368","span":{"begin":381,"end":390},"obj":"Body_part"},{"id":"T369","span":{"begin":414,"end":424},"obj":"Body_part"},{"id":"T370","span":{"begin":468,"end":476},"obj":"Body_part"},{"id":"T371","span":{"begin":480,"end":495},"obj":"Body_part"},{"id":"T372","span":{"begin":501,"end":511},"obj":"Body_part"}],"attributes":[{"id":"A361","pred":"fma_id","subj":"T361","obj":"http://purl.org/sig/ont/fma/fma74413"},{"id":"A362","pred":"fma_id","subj":"T362","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A363","pred":"fma_id","subj":"T363","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A364","pred":"fma_id","subj":"T364","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma66838"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma74413"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma66838"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma63021"},{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A372","pred":"fma_id","subj":"T372","obj":"http://purl.org/sig/ont/fma/fma63014"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"331","span":{"begin":468,"end":478},"obj":"Gene"},{"id":"332","span":{"begin":480,"end":495},"obj":"Chemical"},{"id":"333","span":{"begin":501,"end":511},"obj":"Chemical"},{"id":"334","span":{"begin":57,"end":84},"obj":"Disease"},{"id":"335","span":{"begin":95,"end":107},"obj":"Disease"}],"attributes":[{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Gene:6382"},{"id":"A332","pred":"tao:has_database_id","subj":"332","obj":"MESH:D006497"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"MESH:D006820"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"MESH:D009081"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T74","span":{"begin":62,"end":68},"obj":"Disease"}],"attributes":[{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T343","span":{"begin":45,"end":61},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T344","span":{"begin":249,"end":265},"obj":"http://purl.obolibrary.org/obo/CL_0000115"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T121","span":{"begin":480,"end":495},"obj":"Chemical"},{"id":"T122","span":{"begin":480,"end":487},"obj":"Chemical"},{"id":"T123","span":{"begin":488,"end":495},"obj":"Chemical"},{"id":"T124","span":{"begin":501,"end":511},"obj":"Chemical"}],"attributes":[{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_132153"},{"id":"A125","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_16336"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T87","span":{"begin":444,"end":455},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T4","span":{"begin":480,"end":495},"obj":"GlycoEpitope"}],"attributes":[{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T144","span":{"begin":0,"end":90},"obj":"Sentence"},{"id":"T145","span":{"begin":91,"end":212},"obj":"Sentence"},{"id":"T146","span":{"begin":213,"end":517},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T698","span":{"begin":0,"end":13},"obj":"GO:0005576"},{"id":"T699","span":{"begin":14,"end":22},"obj":"CHEBI:15358;CHEBI:15358"},{"id":"T700","span":{"begin":45,"end":56},"obj":"UBERON:0001986;CL:0000115"},{"id":"T701","span":{"begin":57,"end":61},"obj":"CL:0000115"},{"id":"T702","span":{"begin":249,"end":260},"obj":"UBERON:0001986;CL:0000115"},{"id":"T703","span":{"begin":261,"end":265},"obj":"CL:0000115"},{"id":"T704","span":{"begin":354,"end":367},"obj":"GO:0005576"},{"id":"T705","span":{"begin":368,"end":376},"obj":"CHEBI:15358;CHEBI:15358"},{"id":"T706","span":{"begin":402,"end":413},"obj":"UBERON:0001986"},{"id":"T707","span":{"begin":468,"end":478},"obj":"PR:000001935"},{"id":"T708","span":{"begin":480,"end":495},"obj":"CHEBI:28815;CHEBI:28815"},{"id":"T709","span":{"begin":501,"end":511},"obj":"CHEBI:24751;CHEBI:24751"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}

{"project":"2_test","denotations":[{"id":"32700024-31454337-64991481","span":{"begin":86,"end":88},"obj":"31454337"},{"id":"32700024-28885470-64991482","span":{"begin":298,"end":300},"obj":"28885470"},{"id":"32700024-28885470-64991483","span":{"begin":513,"end":515},"obj":"28885470"}],"text":"Extracellular histones are cytoxic and cause endothelial cell injury and dysfunction [46]. The cytotoxicity primarily occurs within the microcirculatory system, and causes ultrastructural changes and dysfunction. Altered flow dynamics cause further endothelial cell damage and glycocalyx shedding [47] Inflammatory conditions with high concentrations of extracellular histones and cytokines damage the endothelial glycocalyx accompanied by its degradation shedding of syndecan-1, heparan sulfate, and hyaluronan [47]."}