The vascular pathology of COVID-19 is a topic of great interest [37]. Briefly, necropsy and post-mortem biopsies of decedents with COVID-19 reveal macro and microvascular thrombosis involving arteries, veins, arterioles, capillaries and venules in all major organs. Varga and colleagues describe endothelial cell involvement and endotheliitis across vascular beds [38]. Accumulation of inflammatory cells and viral inclusions by histology and electron microscopy, respectively, occurred within the vascular endothelium of the heart, small bowel, kidneys, and lungs. In autopsy and surgical tissues, there was diffuse lymphocytic endotheliitis and apoptotic bodies. It is important to consider that apoptosis may not require host cell viral entry, but rather binding to the cell surface and subsequent proinflammatory and apoptotic pathway signaling [39].