Acknowledgements
The authors thank Murali Aravamudan, Peter Lebowitz, Ajit Rajasekharan, and Mathai Mammen for their insightful reviews and feedback on our research. We also express our gratitude to Patrick Lenehan, Saurav Kumar Verma, Travis Hughes, and Vishy Thiagarajan who helped develop some of the scientific tools that were leveraged for this study.

Additional information
Competing interests
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is affiliated with Janssen. The author has financial interests in Janssen.
is affiliated with Janssen. The author has financial interests in Janssen.
is affiliated with nference. The author has financial interests in nference.
is affiliated with nference. The author has financial interests in nference.
is affiliated with Janssen. The author has financial interests in Janssen.
is affiliated with nference. The author has financial interests in nference.
is affiliated with nference. The author has financial interests in nference.
is affiliated with nference. The author has financial interests in nference.
is affiliated with nference. The author has financial interests in nference.
is affiliated with nference. The author has financial interests in nference.
is affiliated with nference. The author has financial interests in nference.
is affiliated with Janssen. The author has financial interests in Janssen.
is affiliated with Janssen. The author has financial interests in Janssen.
is affiliated with nference. The author has financial interests in nference.
Author contributions
Formal analysis, Investigation, Methodology, Writing - original draft, Writing - review and editing.
Data curation, Software, Formal analysis, Validation, Investigation, Methodology.
Data curation, Software, Formal analysis, Methodology, Writing - original draft.
Data curation, Formal analysis, Visualization.
Data curation, Formal analysis, Methodology, Writing - original draft.
Data curation, Formal analysis, Project administration.
Data curation, Software, Visualization.
Data curation, Formal analysis, Writing - original draft, Writing - review and editing.
Data curation, Formal analysis, Validation.
Data curation, Software, Formal analysis, Methodology, Writing - original draft.
Formal analysis, Supervision, Methodology, Writing - review and editing.
Formal analysis, Supervision, Methodology, Writing - review and editing.
Visualization.
Software.
Formal analysis, Supervision, Investigation, Methodology, Writing - original draft, Project administration, Writing - review and editing.
Resources, Supervision, Project administration, Writing - review and editing.
Resources, Supervision, Funding acquisition, Validation, Project administration, Writing - review and editing.
Conceptualization, Resources, Software, Supervision, Funding acquisition, Validation, Investigation, Writing - original draft, Project administration, Writing - review and editing.

Additional files
Supplementary file 1.  List of studies included in the Single Cell Platform.
The set of studies which have currently been analyzed and made accessible for analysis in the Single Cell Platform are listed below.
Transparent reporting form

Data availability
All single-cell RNAseq data used in this manuscript were obtained from published and freely available sources online. A complete list of these can be found in Supplementary file 1.