Cell cluster annotation In cases where publicly deposited counts matrices are accompanied by author-assigned annotations for individual cells or clusters, we have retained these cell annotations for display in the platform and accompanying analyses. For any study which was not accompanied by a metadata file containing cluster annotations, we have manually labeled clusters based on sets of canonical ‘cluster-defining genes.’ In these cases, we have attempted to leverage annotations and descriptions of gene expression patterns described by study authors in the manuscript text and figures corresponding to the data being analyzed.