We then asked whether this shared pattern of transcriptional heterogeneity among coronavirus receptors is observed in the human small intestine. Indeed, among all enterocytes from a human scRNAseq study, both ANPEP and DPP4 were among the top 1% of genes with similar expression vectors to that of ACE2 (Figure 5—figure supplement 1). We independently validated this observation by computing gene expression correlations from bulk RNA-sequencing of human small intestine samples from GTEx (n = 187), which similarly revealed that DPP4 and ANPEP are among the top 1% of correlated genes to ACE2 (Figure 5—figure supplement 1C). In fact, among all ~18,500 genes mean expression >1 TPM in GTEx small intestine samples, DPP4 shows the second highest correlation to ACE2 (r = 0.95).