Figure 5.  Coronavirus receptors share a transcriptional signature correlated to maturation of small intestinal enterocytes.
(A) Distribution of cosine similarity between the ‘gene expression vectors’ of ACE2 and all genes in a scRNAseq study of the murine small intestine. The gene expression vector corresponds to the set of CP10K values for a given gene in each individual cell from the selected populations in the selected study. (B) Genes similar to ACE2 (cosine similarity >0.4) sorted by literature-derivation association. Arrow indicates a sort option available on the platform. (C) Transcriptional expression of ANPEP correlated to enterocyte maturation in murine small intestine. Violin plots show distribution of ANPEP expression levels in enterocytes at different stages of differentiation. (D) Transcriptional expression of DPP4 correlated to enterocyte maturation in murine small intestine. Violin plots show distribution of DPP4 expression levels in enterocytes at different stages of differentiation.
Figure 5—figure supplement 1.  Coronavirus receptors show highly correlated expression patterns by single cell and bulk RNA-seq in human small intestine.
(A) Distribution of cosine similarity between the ‘gene expression vectors’ of ACE2 and all genes in a scRNAseq study of the human small intestine. (B) Genes similar to ACE2 sorted by literature-derivation association. (C) Gene expression correlations to ACE2 from bulk RNA-sequencing (GTEx) of human small intestine samples.