This analysis highlights a robust expression of ACE2 in tongue keratinocytes that has not been strongly documented in the literature, as evidenced by the weak local context score between ACE2 and keratinocytes (Figure 4B). In fact, we found no previous reports of ACE2 expression in keratinocytes and only one recent report suggesting ACE2 expression in the human tongue based on a combination of bulk RNA-seq and a scRNAseq dataset which has not been made publicly accessible (Xu et al., 2020b). We propose that a subset of ACE2+ tongue keratinocytes may serve as a novel site of SARS-CoV-2 entry and highlight the need to generate additional gene and protein expression data from human tongue samples to further evaluate this hypothesis. Emerging reports of loss of taste (dysgeusia) in otherwise non-symptomatic COVID-19 patients may warrant further study of the tongue in this pathology (Anosmia AAO-HNS, 2020; Shweta, 2020).