Triangulation of ACE2 expression in the respiratory tract with literature-derived insights.
(A) Schematic representation of the respiratory system highlighting key cell types from the nasal cavity, airway and alveoli. Scatterplot shows comparison of percentage of cells with non-zero expression (x-axis) from eight single-cell studies against literature-derived associations: local score (y-axis and size of circles) and global score (transparency of circles). (B) Assessing literature-based and scRNAseq-based associations between ACE2 and respiratory tract cells. On the left, the dimensionality reduction plots show different cell populations associated with lung and olfactory epithelium. On the right, violin plots show the distribution of ACE2 expression levels in selected populations with non-zero expression. The cell types and the literature-derived local and global associations scores are shown.