Association of age with ACE2 expression and co-administered drugs with COVID-19 outcomes.
(A) Among GTEx transverse colon samples (n = 405), ACE2 expression tends to be higher in samples derived from younger individuals. (B) Among GTEx gastroesophageal junction samples, ACE2 expression tends to be higher in samples derived from older individuals. (C) Analysis of differential adverse events between ACE inhibitors and other classes of antihypertensive medications (example shown for beta-blockers), real-world evidence shows that patients taking ACE inhibitors are more likely to experience angioedema of various tissues including the small intestine and epiglottis.