ACE2, DPP4, and ANPEP show similar expression profiles in the renal proximal tubule epithelial cells by scRNAseq and bulk RNA-seq.
(A–C) Cosine similarities between gene expression vectors of all genes and ACE2 (A), DPP4 (B), and ANPEP (C) among all annotated proximal tubule epithelial cells from a human kidney scRNAseq dataset (Stewart et al., 2019). ACE2, DPP4, and ANPEP are reciprocally among the most similar genes to each other. (D–F) Analysis of Pearson correlation coefficients between all genes and ACE2 (D), DPP4 (E), and ANPEP (F) from human kidney cortex samples (GTEx; n = 85). ACE2, DPP4, and ANPEP are reciprocally among the most strongly correlated genes to each other.