IgM monoclonal gammopathy targeting MAG is indeed a rare disease. Lessons from rare diseases often inform us of bold approaches for the treatment of widespread disease. The pioneering work of Aliu and colleagues described in this issue, might serve as a guidepost for designing effective therapeutics to the glycan components of the COVID19 virus. Such endeavors may produce a sweet ending to a tragedy including both the harsh clinical realities of IgM MAG neuropathy and to the horrors of the deadly CoVID‐19 pandemic.