ronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), are all β-coronal viruses [3].
Fig. 1 The virus types and symptoms of 7 important pathogenic human coronaviruses.
Coronaviruses (CoVs) are enveloped single-stranded positive-sense RNA viruses (Fig. 2A), which widely infected vertebrates including humans and animals, to cause respiratory and enteric dise