Traditional Chinese herbal medicine is widely used in the prevention and treatment of viral infectious diseases in China [75]. Some Chinese herbs contain potential anti-SARS-CoV-2 active compounds, especially Hedysarum multijugum maxim, coptidis rhizoma, and forsythiae fructus, which have been catalogued for treating viral respiratory infections [76]. This provides a basis for the application of traditional Chinese medicine polysaccharides in coronavirus. The avian coronavirus causes infectious bronchitis (IB), which is one of the most serious diseases affecting the avian industry worldwide. APS can significantly reduce the replication of IBV in infected chicken embryo kidney (CEK) cells in a dose-dependent manner. The titer of IBV-specific antibodies, lymphocyte proliferation, and the expression levels of interleukin (IL)-1β, IL-2, IL-8, and TNF-a in APS treatment groups were higher than those in the control group. These data suggest that APS enhances the immune response to IBV vaccination in chickens, and is a potential therapeutic agent for inhibiting IBV [77,78]. During the outbreak of SARS coronaviruses in China, RI, as a Chinese medicinal herb, was prepared as an antiviral drug [79]. Polysaccharides isolated from RI have been shown to stimulate the expression of cytokines, such as IL-2 and interferon (INF)-γ, thereby regulating and enhancing non-specific immunological function, humoral immunity and cellular immunity in mice to play antiviral effects [48]. Active compounds derived from cultured Lentinula edodes mycelia (AHCC) is an α-glucan-based standardized mushroom extract that has been extensively investigated as an immunostimulant both in animals and in humans affected by influenza virus, herpes virus, avian influenza virus (AIV), human papillomavirus (HPV), hepatitis B virus (HBV), and human immunodeficiency virus (HIV) by promoting a regulated and protective immune response [80]. Due to its action in promoting a protective response to a wide range of viral infections, which can support its use in the prevention of diseases provoked by a human pathogenic coronavirus, including COVID-19 [80].