nism and good safety. • Some marine and Chinese medicine polysaccharides have strong anti-coronavirus activity. • Polysaccharide adjuvant can enhance the immunity and antiviral effect of vaccine. • Polysaccharides play important roles in antiviral nanomaterial and delivery system. • A new idea to develop COVID-19 vaccine combining polysaccharides and nanotechnology is proposed. 1 Introduction The present outbreak of a coronaviru