PMC:7354481 / 41697-43278 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T285","span":{"begin":372,"end":376},"obj":"Body_part"},{"id":"T286","span":{"begin":499,"end":505},"obj":"Body_part"},{"id":"T287","span":{"begin":761,"end":779},"obj":"Body_part"},{"id":"T288","span":{"begin":774,"end":779},"obj":"Body_part"},{"id":"T289","span":{"begin":980,"end":984},"obj":"Body_part"},{"id":"T290","span":{"begin":1119,"end":1125},"obj":"Body_part"}],"attributes":[{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma84070"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A290","pred":"fma_id","subj":"T290","obj":"http://purl.org/sig/ont/fma/fma84116"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T59","span":{"begin":499,"end":505},"obj":"Body_part"}],"attributes":[{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T252","span":{"begin":0,"end":20},"obj":"Disease"},{"id":"T253","span":{"begin":74,"end":82},"obj":"Disease"},{"id":"T254","span":{"begin":473,"end":481},"obj":"Disease"},{"id":"T255","span":{"begin":814,"end":834},"obj":"Disease"},{"id":"T256","span":{"begin":858,"end":875},"obj":"Disease"},{"id":"T257","span":{"begin":858,"end":866},"obj":"Disease"},{"id":"T258","span":{"begin":881,"end":887},"obj":"Disease"},{"id":"T259","span":{"begin":943,"end":949},"obj":"Disease"},{"id":"T260","span":{"begin":1112,"end":1118},"obj":"Disease"},{"id":"T261","span":{"begin":1180,"end":1204},"obj":"Disease"},{"id":"T262","span":{"begin":1195,"end":1204},"obj":"Disease"},{"id":"T263","span":{"begin":1230,"end":1249},"obj":"Disease"},{"id":"T264","span":{"begin":1504,"end":1519},"obj":"Disease"},{"id":"T265","span":{"begin":1510,"end":1519},"obj":"Disease"}],"attributes":[{"id":"A252","pred":"mondo_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/MONDO_0007264"},{"id":"A253","pred":"mondo_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A254","pred":"mondo_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A255","pred":"mondo_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A256","pred":"mondo_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/MONDO_0005271"},{"id":"A257","pred":"mondo_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/MONDO_0004980"},{"id":"A258","pred":"mondo_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/MONDO_0004979"},{"id":"A259","pred":"mondo_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/MONDO_0021042"},{"id":"A260","pred":"mondo_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/MONDO_0021042"},{"id":"A261","pred":"mondo_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/MONDO_0007256"},{"id":"A262","pred":"mondo_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"},{"id":"A263","pred":"mondo_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/MONDO_0004975"},{"id":"A264","pred":"mondo_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A265","pred":"mondo_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T476","span":{"begin":24,"end":25},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T477","span":{"begin":91,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T478","span":{"begin":278,"end":279},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T479","span":{"begin":372,"end":376},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T480","span":{"begin":526,"end":527},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T481","span":{"begin":624,"end":633},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T482","span":{"begin":665,"end":675},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T483","span":{"begin":725,"end":728},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T484","span":{"begin":761,"end":779},"obj":"http://purl.obolibrary.org/obo/CL_0000815"},{"id":"T485","span":{"begin":792,"end":793},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T486","span":{"begin":889,"end":892},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T487","span":{"begin":907,"end":910},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T488","span":{"begin":980,"end":984},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T489","span":{"begin":1055,"end":1057},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T490","span":{"begin":1055,"end":1057},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T491","span":{"begin":1075,"end":1076},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T492","span":{"begin":1263,"end":1266},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T493","span":{"begin":1349,"end":1352},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T494","span":{"begin":1384,"end":1385},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T161","span":{"begin":325,"end":334},"obj":"Chemical"},{"id":"T162","span":{"begin":1016,"end":1030},"obj":"Chemical"},{"id":"T163","span":{"begin":1055,"end":1057},"obj":"Chemical"},{"id":"T167","span":{"begin":1386,"end":1395},"obj":"Chemical"}],"attributes":[{"id":"A161","pred":"chebi_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/CHEBI_59163"},{"id":"A162","pred":"chebi_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/CHEBI_26561"},{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_51079"},{"id":"A164","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_139019"},{"id":"A165","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_140152"},{"id":"A166","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_34826"},{"id":"A167","pred":"chebi_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/CHEBI_59163"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T78","span":{"begin":0,"end":20},"obj":"Phenotype"},{"id":"T79","span":{"begin":161,"end":180},"obj":"Phenotype"},{"id":"T80","span":{"begin":814,"end":834},"obj":"Phenotype"},{"id":"T81","span":{"begin":881,"end":887},"obj":"Phenotype"},{"id":"T82","span":{"begin":943,"end":949},"obj":"Phenotype"},{"id":"T83","span":{"begin":1112,"end":1118},"obj":"Phenotype"},{"id":"T84","span":{"begin":1180,"end":1204},"obj":"Phenotype"},{"id":"T85","span":{"begin":1230,"end":1249},"obj":"Phenotype"},{"id":"T86","span":{"begin":1404,"end":1411},"obj":"Phenotype"}],"attributes":[{"id":"A78","pred":"hp_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/HP_0001645"},{"id":"A79","pred":"hp_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/HP_0001685"},{"id":"A80","pred":"hp_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A81","pred":"hp_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A82","pred":"hp_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/HP_0009733"},{"id":"A83","pred":"hp_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/HP_0009733"},{"id":"A84","pred":"hp_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/HP_0001402"},{"id":"A85","pred":"hp_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/HP_0002511"},{"id":"A86","pred":"hp_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/HP_0001250"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T154","span":{"begin":665,"end":684},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T155","span":{"begin":665,"end":675},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T156","span":{"begin":960,"end":975},"obj":"http://purl.obolibrary.org/obo/GO_0045926"},{"id":"T157","span":{"begin":969,"end":975},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T158","span":{"begin":980,"end":990},"obj":"http://purl.obolibrary.org/obo/GO_0007049"},{"id":"T159","span":{"begin":1504,"end":1519},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"LitCovid-sentences","denotations":[{"id":"T275","span":{"begin":0,"end":216},"obj":"Sentence"},{"id":"T276","span":{"begin":217,"end":512},"obj":"Sentence"},{"id":"T277","span":{"begin":513,"end":691},"obj":"Sentence"},{"id":"T278","span":{"begin":692,"end":1211},"obj":"Sentence"},{"id":"T279","span":{"begin":1212,"end":1345},"obj":"Sentence"},{"id":"T280","span":{"begin":1346,"end":1472},"obj":"Sentence"},{"id":"T281","span":{"begin":1473,"end":1581},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

{"project":"2_test","denotations":[{"id":"32512929-29515035-144200781","span":{"begin":507,"end":510},"obj":"29515035"},{"id":"32512929-29515035-144200782","span":{"begin":686,"end":689},"obj":"29515035"},{"id":"32512929-32348937-144200783","span":{"begin":889,"end":892},"obj":"32348937"},{"id":"32512929-28239651-144200784","span":{"begin":1133,"end":1136},"obj":"28239651"},{"id":"32512929-28469953-144200785","span":{"begin":1206,"end":1209},"obj":"28469953"},{"id":"32512929-31949677-144200786","span":{"begin":1340,"end":1343},"obj":"31949677"},{"id":"32512929-18055455-144200787","span":{"begin":1468,"end":1470},"obj":"18055455"}],"text":"Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated."}

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