Acknowledgments
We thank Paul E Verweij M.D. for helpful discussions.

Author Contributions
Conceptualization, J.F.M. and A.S.M.D.; formal analysis, E.F.J.M.; investigation, O.H. and J.B.B.; resources, J.F.M.; data curation, A.S.M.D. and O.H.; writing—original draft preparation, E.M. and J.F.M.; writing—review and editing, A.S.M.D., O.H., J.B.B.; supervision, J.F.M. All authors have read and agreed to the published version of the manuscript.

Funding
This research received no external funding.

Conflicts of Interest
The authors declare no conflict of interest.