PMC:7344504 / 12084-13299 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7344504","sourcedb":"PMC","sourceid":"7344504","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7344504","text":"Serum galactomannan testing has been shown to be a fairly sensitive diagnostic tool (70%) in neutropenic patients with pathology-proven invasive aspergillosis [27,28]. However, in patients who are non-neutropenic, serum galactomannan sensitivity of around 25% has been reported [27], which may explain the low number of serum galactomannan positive findings in recently published case reports [6,7] and case series [3,4,5]. The role of β-d-glucan and the Aspergillus-specific lateral flow device (LFD) as an adjunct to the diagnosis of IPA in COVID-19 is not yet clear [2,23]. Serum β-d-glucan was persistently strongly positive in this patient over the course of a week. The specificity for invasive fungal disease of β-d-glucan testing in a mixed ICU population has been shown to be high (86%), with two consecutive positive results [29] compared to those with only fungal colonization and no invasive fungal disease. In addition, multiple other studies report a good sensitivity for the diagnosis of invasive aspergillosis in critically ill patients [30,31,32,33,34]. BAL β-d-glucan in the ICU setting is, however, not recommended, due to its poor specificity and confounders causing false positive results 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