In conclusion, we report a case of IPA in a patient with severe pneumonia associated with COVID-19. Using a gold standard method (histopathology) in our case series, the frequency of IPA was lower, as compared to that of cases published elsewhere; possible overestimation might be due to contamination. In our case, no CT imaging of the lung, sequential GM, or culture for fungus was performed, thus reinforcing the role of autopsies as a form of postmortem surveillance of such a severe disease. As the outbreak of COVID-19 continues to spread around the world, further reports are needed to assess the occurrence and frequency of IPA in severe SARS-CoV-2 infections, and their clinical interaction. These studies are needed to assess the incidence of IPA and define at-risk populations, thus offering a strategy for diagnosis, prophylaxis, and timely clinical management.