4  Concluding remarks
Among all the proteins present in the novel RNA virus, some accessory proteins such as ORF6, ORF7b, ORF8, ORF10 contain the least number of missense mutation as reported in various studies [[14], [15], [16]]. And same is true for E-protein. We find 15 among 3617 (0.414%) of the SARS-CoV2 genome contains eight different types of mutations in TMD and C-terminus of the envelope protein. Mutated E-protein might affect replication and propagation of the SARS-CoV2 as has been observed in cases of SARS-CoV and MERS-CoV in mouse model [17]. Potential studies have also shown that vaccine against the E-protein mutated viruses can reduce the infectivity in mouse model.