Table 1 Non- synonymous mutation in the E-protein of SARS-CoV2. Protein-ID Geo-location Mutation Domain Change of R-group QJA42107 USA: VA A36V TMDa Hydrophobic to Hydrophobic QJQ84222 USA: KENNER, LA L26F TMD Hydrophobic to Hydrophobic QHZ00381 South Korea L37H TMD Hydrophobic to Hydrophilic QJS53352 Greece: Athens L39M TMD Hydrophobic to Hydrophobic QJR88103 Australia: Victoria L73F C-terminus Hydrophobic to Hydrophobic QKE45838 USA: CA P71L C-terminus Hydrophobic to Hydrophobic QKE45886 USA: CA P71L C-terminus Hydrophobic to Hydrophobic QKE45898 USA: CA P71L C-terminus Hydrophobic to Hydrophobic QKE45910 USA: CA P71L C-terminus Hydrophobic to Hydrophobic QJE38284 USA: CA P71L C-terminus Hydrophobic to Hydrophobic QIU81527 USA: WA P71L C-terminus Hydrophobic to Hydrophobic QKG87268 USA: Massachusetts S68F C-terminus Hydrophobic to Hydrophobic QKG88576 USA: Massachusetts S68F C-terminus Hydrophobic to Hydrophobic QKI36831 China: Guangzhou D72Y C-terminus Hydrophilic to Hydrophobic QKI36855 China: Guangzhou S68C C-terminus Hydrophilic to Hydrophobic a TMD: transmembrane domain.