As most of the cited trials utilize a mixture of DHA and EPA which may mask the effects of each compound, the individual effects of DHA or EPA in obese patients were also investigated, but the results were inconclusive. A significant reduction in serum IL-18 and adiponectin with DHA than with EPA was observed in one study (Allaire et al., 2016), while no differences between DHA and EPA in the expression of pro-inflammatory genes were observed in another study (Vors et al., 2017).