PMC:7335494 / 54309-58166
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T388 | 332-345 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T389 | 332-336 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T390 | 683-687 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T391 | 713-726 | Body_part | denotes | phospholipids | http://purl.org/sig/ont/fma/fma82779 |
| T392 | 788-795 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T393 | 805-819 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T394 | 823-828 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T395 | 935-946 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T396 | 1019-1030 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T397 | 1273-1284 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T398 | 1486-1496 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T399 | 1529-1533 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T400 | 1693-1698 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T401 | 1708-1718 | Body_part | denotes | peroxisome | http://purl.org/sig/ont/fma/fma63845 |
| T402 | 1806-1813 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T403 | 1831-1840 | Body_part | denotes | G-protein | http://purl.org/sig/ont/fma/fma61788 |
| T404 | 1881-1903 | Body_part | denotes | cell adhesion molecule | http://purl.org/sig/ont/fma/fma67214 |
| T405 | 1881-1885 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T406 | 1907-1911 | Body_part | denotes | ICAM | http://purl.org/sig/ont/fma/fma67857 |
| T407 | 1930-1952 | Body_part | denotes | cell adhesion molecule | http://purl.org/sig/ont/fma/fma67214 |
| T408 | 1930-1934 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T409 | 2028-2036 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T410 | 2053-2060 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T411 | 2495-2508 | Body_part | denotes | phospholipids | http://purl.org/sig/ont/fma/fma82779 |
| T412 | 2648-2666 | Body_part | denotes | lipopolysaccharide | http://purl.org/sig/ont/fma/fma82785 |
| T413 | 2690-2695 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T414 | 2805-2809 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T415 | 2810-2823 | Body_part | denotes | phospholipids | http://purl.org/sig/ont/fma/fma82779 |
| T416 | 2828-2834 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T417 | 3055-3060 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T418 | 3373-3382 | Body_part | denotes | leukocyte | http://purl.org/sig/ont/fma/fma62852 |
| T419 | 3818-3823 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T420 | 3824-3833 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T67 | 805-819 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T68 | 813-819 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T69 | 823-828 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T70 | 3818-3823 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T163 | 187-199 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T164 | 688-700 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T165 | 1099-1111 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T166 | 1294-1306 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T167 | 1360-1372 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T168 | 1591-1603 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T585 | 332-336 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T586 | 337-345 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T587 | 531-534 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T588 | 608-612 | http://purl.obolibrary.org/obo/NCBITaxon_117565 | denotes | fish |
| T589 | 626-627 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T590 | 683-687 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T591 | 805-819 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T592 | 823-828 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T593 | 823-828 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T594 | 823-828 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T595 | 823-828 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T596 | 1120-1121 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T597 | 1216-1220 | http://purl.obolibrary.org/obo/CLO_0050768 | denotes | TLR2 |
| T598 | 1238-1247 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T599 | 1252-1253 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T600 | 1310-1320 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T601 | 1447-1448 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T602 | 1497-1498 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T603 | 1632-1633 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T604 | 1681-1690 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T605 | 1691-1698 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T606 | 1732-1741 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T607 | 1753-1757 | http://purl.obolibrary.org/obo/CLO_0050768 | denotes | TLR2 |
| T608 | 1796-1805 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T609 | 1831-1857 | http://purl.obolibrary.org/obo/PR_000030035 | denotes | G-protein coupled receptor |
| T610 | 1881-1885 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T611 | 1930-1934 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T612 | 2028-2036 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T613 | 2247-2248 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T614 | 2307-2309 | http://purl.obolibrary.org/obo/CLO_0002860 | denotes | E2 |
| T615 | 2380-2382 | http://purl.obolibrary.org/obo/CLO_0008426 | denotes | PG |
| T616 | 2564-2565 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T617 | 2678-2695 | http://purl.obolibrary.org/obo/CL_0000842 | denotes | mononuclear cells |
| T618 | 2703-2704 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T619 | 2757-2758 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T620 | 2793-2809 | http://purl.obolibrary.org/obo/CL_0000842 | denotes | mononuclear cell |
| T621 | 2828-2834 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T622 | 2857-2858 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T623 | 3210-3211 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T624 | 3326-3328 | http://purl.obolibrary.org/obo/CLO_0001818 | denotes | B5 |
| T625 | 3361-3367 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T626 | 3371-3372 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T627 | 3617-3618 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T628 | 3748-3749 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T629 | 3818-3823 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T630 | 3818-3823 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T631 | 3824-3833 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T182 | 47-52 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T56757 | 101-106 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T6269 | 207-212 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T43446 | 298-302 | Chemical | denotes | PUFA | http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567 |
| T59382 | 454-465 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T188 | 467-476 | Chemical | denotes | resolvins | http://purl.obolibrary.org/obo/CHEBI_132120 |
| T31811 | 591-594 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T193 | 599-602 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T39688 | 664-667 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T198 | 672-675 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T91911 | 713-726 | Chemical | denotes | phospholipids | http://purl.obolibrary.org/obo/CHEBI_16247 |
| T95831 | 764-767 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T33708 | 771-774 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T205 | 927-946 | Chemical | denotes | omega-3 fatty acids | http://purl.obolibrary.org/obo/CHEBI_25681 |
| T66251 | 935-946 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T207 | 941-946 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T208 | 951-962 | Chemical | denotes | polyphenols | http://purl.obolibrary.org/obo/CHEBI_26195 |
| T68806 | 1019-1030 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T65512 | 1025-1030 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T63648 | 1079-1083 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T31400 | 1116-1118 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T215 | 1248-1250 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T4660 | 1265-1284 | Chemical | denotes | omega-3 fatty acids | http://purl.obolibrary.org/obo/CHEBI_25681 |
| T219 | 1273-1284 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T68636 | 1279-1284 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T72652 | 1443-1445 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T89468 | 1486-1496 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T95152 | 1492-1496 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T25236 | 1551-1555 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T227 | 1605-1609 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T56528 | 1611-1626 | Chemical | denotes | prostaglandin 2 | http://purl.obolibrary.org/obo/CHEBI_133370 |
| T20702 | 1611-1624 | Chemical | denotes | prostaglandin | http://purl.obolibrary.org/obo/CHEBI_26333 |
| T79435 | 1628-1630 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T17469 | 1788-1795 | Chemical | denotes | mitogen | http://purl.obolibrary.org/obo/CHEBI_52290 |
| T2710 | 1806-1813 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T235 | 1833-1840 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T52907 | 1895-1903 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T51951 | 1944-1952 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T238 | 2013-2018 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T5342 | 2020-2023 | Chemical | denotes | MCP | http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099 |
| T61692 | 2053-2060 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T72115 | 2071-2074 | Chemical | denotes | AMP | http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215 |
| T245 | 2094-2099 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T90540 | 2126-2131 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T247 | 2137-2140 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T248 | 2181-2184 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T21252 | 2189-2199 | Chemical | denotes | eicosanoid | http://purl.obolibrary.org/obo/CHEBI_23899 |
| T16433 | 2211-2214 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T72235 | 2229-2232 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T18036 | 2293-2309 | Chemical | denotes | prostaglandin E2 | http://purl.obolibrary.org/obo/CHEBI_15551|http://purl.obolibrary.org/obo/CHEBI_606564 |
| T29972 | 2293-2306 | Chemical | denotes | prostaglandin | http://purl.obolibrary.org/obo/CHEBI_26333 |
| T19788 | 2311-2315 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T68795 | 2367-2370 | Chemical | denotes | ALA | http://purl.obolibrary.org/obo/CHEBI_16449|http://purl.obolibrary.org/obo/CHEBI_27432 |
| T258 | 2380-2382 | Chemical | denotes | PG | http://purl.obolibrary.org/obo/CHEBI_14336|http://purl.obolibrary.org/obo/CHEBI_18208|http://purl.obolibrary.org/obo/CHEBI_61695|http://purl.obolibrary.org/obo/CHEBI_64716|http://purl.obolibrary.org/obo/CHEBI_64961 |
| T89083 | 2401-2404 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T67193 | 2437-2440 | Chemical | denotes | ALA | http://purl.obolibrary.org/obo/CHEBI_16449|http://purl.obolibrary.org/obo/CHEBI_27432 |
| T94171 | 2445-2447 | Chemical | denotes | LA | http://purl.obolibrary.org/obo/CHEBI_17351|http://purl.obolibrary.org/obo/CHEBI_73527 |
| T268 | 2472-2477 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T59126 | 2495-2508 | Chemical | denotes | phospholipids | http://purl.obolibrary.org/obo/CHEBI_16247 |
| T25844 | 2572-2575 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T49673 | 2629-2633 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T72850 | 2648-2666 | Chemical | denotes | lipopolysaccharide | http://purl.obolibrary.org/obo/CHEBI_16412 |
| T18964 | 2735-2738 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T64527 | 2810-2823 | Chemical | denotes | phospholipids | http://purl.obolibrary.org/obo/CHEBI_16247 |
| T38766 | 2902-2905 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T4159 | 2993-2997 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T6510 | 2999-3002 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T28793 | 3007-3010 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T51672 | 3055-3060 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T283 | 3082-3085 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T39421 | 3116-3130 | Chemical | denotes | prostaglandins | http://purl.obolibrary.org/obo/CHEBI_26333 |
| T285 | 3150-3162 | Chemical | denotes | leukotrienes | http://purl.obolibrary.org/obo/CHEBI_25029 |
| T22263 | 3252-3262 | Chemical | denotes | eicosanoid | http://purl.obolibrary.org/obo/CHEBI_23899 |
| T287 | 3302-3305 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T1293 | 3314-3328 | Chemical | denotes | leukotriene B5 | http://purl.obolibrary.org/obo/CHEBI_88493 |
| T7758 | 3314-3325 | Chemical | denotes | leukotriene | http://purl.obolibrary.org/obo/CHEBI_25029 |
| T290 | 3330-3334 | Chemical | denotes | LTB5 | http://purl.obolibrary.org/obo/CHEBI_88493 |
| T31572 | 3404-3407 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T84097 | 3416-3420 | Chemical | denotes | LTB4 | http://purl.obolibrary.org/obo/CHEBI_15647 |
| T293 | 3461-3464 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T49800 | 3509-3512 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T56648 | 3548-3551 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T26739 | 3592-3595 | Chemical | denotes | ARA | http://purl.obolibrary.org/obo/CHEBI_15843 |
| T297 | 3604-3608 | Chemical | denotes | PGD2 | http://purl.obolibrary.org/obo/CHEBI_15555 |
| T86697 | 3674-3678 | Chemical | denotes | PGD2 | http://purl.obolibrary.org/obo/CHEBI_15555 |
| T4872 | 3716-3719 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T163 | 187-199 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T164 | 377-386 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T165 | 688-700 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T166 | 970-1009 | http://purl.obolibrary.org/obo/GO_0050727 | denotes | regulation of the inflammatory response |
| T167 | 970-980 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T168 | 988-1009 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T169 | 1031-1064 | http://purl.obolibrary.org/obo/GO_0050728 | denotes | inhibit the inflammatory response |
| T170 | 1043-1064 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T171 | 1099-1111 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T172 | 1168-1191 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcriptional factors |
| T173 | 1168-1183 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T174 | 1294-1306 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T175 | 1321-1325 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T176 | 1360-1372 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T177 | 1386-1419 | http://purl.obolibrary.org/obo/GO_0050728 | denotes | inhibit the inflammatory response |
| T178 | 1398-1419 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T179 | 1537-1541 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T180 | 1591-1603 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T181 | 1708-1731 | http://purl.obolibrary.org/obo/GO_0016559 | denotes | peroxisome proliferator |
| T182 | 1781-1785 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T183 | 1881-1903 | http://purl.obolibrary.org/obo/GO_0098631 | denotes | cell adhesion molecule |
| T184 | 1881-1894 | http://purl.obolibrary.org/obo/GO_0007155 | denotes | cell adhesion |
| T185 | 1930-1952 | http://purl.obolibrary.org/obo/GO_0098631 | denotes | cell adhesion molecule |
| T186 | 1930-1943 | http://purl.obolibrary.org/obo/GO_0007155 | denotes | cell adhesion |
| T187 | 1997-2005 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T188 | 1997-2005 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T189 | 1997-2005 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T190 | 1997-2005 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T191 | 2064-2068 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T192 | 2064-2068 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T193 | 2064-2068 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T194 | 2200-2209 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T195 | 2233-2243 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T196 | 2383-2395 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
| T197 | 3039-3051 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T308 | 0-52 | Sentence | denotes | 6.1 Inflammatory-resolving effects induced by PUFAs |
| T309 | 53-167 | Sentence | denotes | Nowadays, the mechanisms of action by which n-3 PUFAs regulate the inflammatory processes are widely investigated. |
| T310 | 168-527 | Sentence | denotes | The suppression of inflammation by n-3 PUFAs is associated with one of the following mechanisms (1) competitive inhibition of n-6 PUFA pathway; (2) modification of cell membrane composition; (3) affecting the formation of rafts or (4) direct anti-inflammatory effect of their bioactive metabolites (resolvins, protectins, and maresins) (Poudyal et al., 2011). |
| T311 | 528-905 | Sentence | denotes | It has been demonstrated that the dietary supplementation with DHA and EPA from fish increases in a dose-response manner the content of DHA and EPA in the cell inflammation-responsible phospholipids (Calder, 2017); increased content of DHA or EPA in different tissues, such as adipose tissue or heart was also observed in correlation with their intake (Calder, 2015) (Fig. 3 ). |
| T312 | 906-1010 | Sentence | denotes | Fig. 3 The effect of omega-3 fatty acids and polyphenols in the regulation of the inflammatory response. |
| T313 | 1011-1254 | Sentence | denotes | Omega-3 fatty acids inhibit the inflammatory response by inhibiting PGE2 which promotes inflammation and NF-κB either directly, via the interaction with the transcriptional factors PPARs, or by inhibiting TLR2/4 which normally activates NF-κB. |
| T314 | 1255-1373 | Sentence | denotes | Moreover, omega-3 fatty acids regulate inflammation by activating MAPK and GPR120 which in turn inhibits inflammation. |
| T315 | 1374-1467 | Sentence | denotes | Polyphenols inhibit the inflammatory response by directly inhibiting NF-κB, or via the PPARs. |
| T316 | 1468-2083 | Sentence | denotes | They also promote fatty acid b-oxidation and inhibit VCAM-1, ICAM-1, MAPK pathway, PGE2 and COX-2 that all promote chronic inflammation (PGE2 –prostaglandin 2; NF-κB – nuclear factor kappa-light-chain-enhancer of activated B cells; PPARs – peroxisome proliferator-activated receptors; TLR2/4– toll-like receptor; MAPK – mitogen-activated protein kinase; GPR120 – G-protein coupled receptor 120; VCAM-1 – vascular cell adhesion molecule 1; ICAM-1 – intracellular cell adhesion molecule 1; COX-2 – cyclooxygenase 2; TNF-α – tumour necrosis factor alpha; MCP-1 – monocyte chemoattractant protein 1; AMPK – AMP kinase). |
| T317 | 2084-2210 | Sentence | denotes | These n-3 PUFAs frequently substitute n-6 PUFAs like ARA, resulting in decreased availability of ARA for eicosanoid synthesis. |
| T318 | 2211-2328 | Sentence | denotes | EPA also inhibits ARA metabolism as a competitive substrate for COX-2, decreasing prostaglandin E2 (PGE2) production. |
| T319 | 2329-2524 | Sentence | denotes | In rats, dietary supplementation with ALA inhibits PG biosynthesis from ARA, while equivalent quantities of ALA and LA decreased up to 40% n-6 PUFAs incorporation in phospholipids (Calder, 2017). |
| T320 | 2525-2734 | Sentence | denotes | Furthermore, Rees et al. observed that a daily EPA intake of 2.7 g or 4.05 g for 3 months decreases the PGE2 production by lipopolysaccharide-stimulated mononuclear cells, while a lower dose of 1.35 g did not. |
| T321 | 2735-2835 | Sentence | denotes | EPA was integrated in a linear dose-dependent manner into mononuclear cell phospholipids and plasma. |
| T322 | 2836-2959 | Sentence | denotes | This study suggested a daily threshold in the range of 1.35–2.7 g EPA for the anti-inflammatory action (Rees et al., 2006). |
| T323 | 2960-3288 | Sentence | denotes | Besides decreasing production of PGE2, DHA and EPA are also substrates for the biosynthesis of lipid derivatives, but the EPA-derived mediators as series-3 prostaglandins (PGD3) or series-5 leukotrienes are typically less biologically potent, having a lower ability to interact with relevant eicosanoid receptors (Calder, 2015). |
| T324 | 3289-3436 | Sentence | denotes | For example, EPA-derived leukotriene B5 (LTB5) is almost 100 times less active as a leukocyte chemoattractant than ARA-derived LTB4 (Calder, 2017). |
| T325 | 3437-3531 | Sentence | denotes | However, in some cases, EPA-derived mediators have similar potency with ARA-derived mediators. |
| T326 | 3532-3699 | Sentence | denotes | It appears that EPA-derived PGD3 inhibits the effect of the ARA-derived PGD2, due to a stronger interaction with the DP1 receptor compared to PGD2 (Wada et al., 2007). |
| T327 | 3700-3857 | Sentence | denotes | In other cases, EPA-derived mediators exhibited a similar magnitude of effect (e.g. inhibition of TNF-α production by blood monocytes) (Dooper et al., 2002). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T94 | 1990-1996 | Phenotype | denotes | tumour | http://purl.obolibrary.org/obo/HP_0002664 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-21762726-30720915 | 521-525 | 21762726 | denotes | 2011 |
| 32640331-28900017-30720916 | 736-740 | 28900017 | denotes | 2017 |
| 32640331-25149823-30720917 | 889-893 | 25149823 | denotes | 2015 |
| 32640331-28900017-30720918 | 2518-2522 | 28900017 | denotes | 2017 |
| 32640331-16469992-30720919 | 2953-2957 | 16469992 | denotes | 2006 |
| 32640331-25149823-30720920 | 3282-3286 | 25149823 | denotes | 2015 |
| 32640331-28900017-30720921 | 3430-3434 | 28900017 | denotes | 2017 |
| 32640331-17519235-30720922 | 3693-3697 | 17519235 | denotes | 2007 |
| 32640331-12225374-30720923 | 3851-3855 | 12225374 | denotes | 2002 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-21762726-30720915 | 521-525 | 21762726 | denotes | 2011 |
| 32640331-28900017-30720916 | 736-740 | 28900017 | denotes | 2017 |
| 32640331-25149823-30720917 | 889-893 | 25149823 | denotes | 2015 |
| 32640331-28900017-30720918 | 2518-2522 | 28900017 | denotes | 2017 |
| 32640331-16469992-30720919 | 2953-2957 | 16469992 | denotes | 2006 |
| 32640331-25149823-30720920 | 3282-3286 | 25149823 | denotes | 2015 |
| 32640331-28900017-30720921 | 3430-3434 | 28900017 | denotes | 2017 |
| 32640331-17519235-30720922 | 3693-3697 | 17519235 | denotes | 2007 |
| 32640331-12225374-30720923 | 3851-3855 | 12225374 | denotes | 2002 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T25 | 1374-1385 | CHEBI:26195;CHEBI:26195 | denotes | Polyphenols |