Noteworthy, LA, ARA, EPA and DHA are important constituents of membrane phospholipids and have important roles in membrane function, which greatly influences cell activity (Burdge and Calder, 2015). The proportion of PUFAs found in the membrane is dependent on cell type, dietary intake and metabolism (Calder, 2017). For example, in healthy subjects receiving a typical Western diet, the percentages of DHA, EPA, and ARA, in mononuclear cells were 2.5, 0.5 and, respectively, 20% of total fatty acids (Calder, 2011).