High fat high sucrose diet (HFD) C57BL/6 J (wild type; WT) male mice 8-week treatment:➢ Young + normal diet (YND)
➢ Young + HFD (YHFD)
➢ Old + normal diet (OND)
➢ Old + HFD (OHFD) HFD led to β-cell failure in aged mice, enhanced expression of pro-inflammatory cytokines and macrophage transformation to a more pro-inflammatory phenotype He et al. (2018)