Diet supplemented with ketones Knockout mice model for Muckle-Wells Syndrome and Familial Cold Autoinflammatory syndrome 1-week treatment:➢ Control: normal chow with 4.5% fat ➢ Study group: normal chow supplemented with 20% 1,3-butanediol ketone diesters Study group: ↓ IL-1β release and caspase-1 activity Youm et al. (2015)