Carbohydrate-restricted diet Senescence-accelerated prone mice (SAMP8) 8-week treatment:➢ Control: standard chow
➢ High fat diet group (HFD)
➢ Carbohydrate-restricted diet group (CRD) CRD: ↑ IL-6 and IL-1β, ↓cecum short-chain fatty acids He et al. (2019)