f inflammation. • Omega-3 polyunsaturated fatty acids have beneficial effects in chronic disease. • Polyphenols inhibit the inflammatory processes through multiple pathways. • Carbohydrate restriction and Mediterranean diet generate reduction of inflammatory markers in clinical studies. 1 Introduction Non-communicable diseases (NCDs), the silent epidemic, are responsible for the majority of deaths in developed countries and their prevalence at a younger age was observed increasingly in the last years (WHO, 2013, 2018). Cardiovascular disease (CVD), diabetes, obesity, cancer, Alzheimer's and Parkinson's