L-8, VEGF are released. Further, the inflammatory response elicited by dysfunctional adipocytes, hypoxia, adipocyte expansion, and impaired fatty acids storage is accelerated by formation of reactive species, either oxygen (ROS) or nitrogen (RNS) (Crewe et al., 2017; Demaria et al., 2014; Fujisaka et al., 2013; Margina et al., 2012; Pasarica et al., 2009; Paun et