Resource Availability Lead Contact Further information and requests for resources and reagents should be directed to and will be fulfilled by Nevan J. Krogan (Nevan.Krogan@ucsf.edu). Materials Availability Plasmid pLVX-TetOne-Puro-SARS-CoV-2-N-2xStrep is available upon request from the Lead Contact. Data and Code Availability The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD019113 (Perez-Riverol et al., 2019). An interactive version of phosphorylation data can be found at https://kroganlab.ucsf.edu/network-maps. Supplementary tables have been deposited to Mendeley Data: https://dx.doi.org/10.17632/dpkbh2g9hy.1.