One such, to-date neglected population that is potentially more »vulnerable« to COVID-19 consists of prematurely born individuals. Given that preterm birth prevalence is currently estimated at approximately 10 % births worldwide, the potential consequences of prematurity relate to a significant part of the population. We argue, that three important features associated with prematurity constitute the basis of such probable vulnerability: First, the detrimental long-term consequences on respiratory system development, control and function. Second, higher levels of (and possibly reduced tolerance to) oxidative stress and third, potentially elevated Angiotensin-converting enzyme (ACE2) activity/expression.