Table 2 Reported cases of COVID 19 in transplant patients. MMF = Mycophenolate Mofetil. WBC = White blood cell count. CRP = C-reactive protein. LDH = lactate dehydrogenase.
Age/ Sex Solid Organ Transplant ChronicImmunomodulator Medications given during admission while receivingCOVID treatment IL-6 levels WBC(4.5–11 × 109/L) Lymphocytes (30–45 %) CRP(<0.8 mg/dL; <76.2 nmol/L) LDH(80–225 units/L) Outcome Total Days of Illness Citation
37M Liver Tacrolimus Oseltamivir, phosphate capsules, cefoperazonesulbactam sodium, methylprednisoloneTacrolimus discontinued Not Reported 2.46 48% Not reported Not Reported Acute transplant rejection, but recovered after tacrolimus was resumedFull recovery 15 days [4]
48M Kidney, 2003 Tacrolimus MMF Oseltamivir, abidol moxifloxacin, recombinant human interferon alpha, methylprednisolone, human IVIG TacrolimusMMF discontinued Not Reported 2.49 64% 31.25 Not Reported Bone marrow suppression due to MMFFull recovery 42 days [4]
38M Kidney, 2019 Glucocorticoid MMF Tacrolimus Oseltamivir, arbidol Glucocorticoids TacrolimusMMF discontinued Not Reported 4.73 63% 0.37 193 Full recovery 26 days [5]
64M Kidney, 2016 Glucocorticoid MMF rapamycin Oseltamivir or arbidol cefepime and IVIG Glucocorticoids TacrolimusMMF discontinued Not Reported 17.67 55% 1.26 180 Remained hospitalized Not Reported [5]
37F Kidney, 2019 Glucocorticoid MMF Tacrolimus Oseltamivir or arbidol cefepimeIVIG GlucocorticoidsMMF discontinuedTacrolimus discontinued, then restarted at half the dose Not Reported 5.67 31% 2.03 160 Remained hospitalized 22 days [5]
47M Kidney, 2019 Glucocorticoid MMF Tacrolimus Oseltamivir or arbidol GlucocorticoidsMMF discontinuedTacrolimus stopped and restarted Not Reported 3.99 51% 0.45 235 Remained hospitalized Not Reported [5]
38M Kidney, 2017 Glucocorticoid MMF Tacrolimus Oseltamivir or arbidol Glucocorticoids MMF Tacrolimus Not Reported 6.44 91% 0.39 248 Full recovery 23 days [5]
50 M Liver Tacrolimus Methylprednisolone. Umifenovir, Lopinavir/ritonavir,IVIG,Cefoperazone, alpha interferonTacrolimus discontinued for 4 weeks due to lymphopenia Not Reported 5.9 72% 32.1 Not Reported Full recovery 28 days [6]
49M Kidney Cyclosporine MMF Prednisone Lopinavir, ritonavir, ribavirin, interferon alpha-2b, methylprednisolone, MMF, prednisoneCyclosporine discontinued Not Reported 7.18 59% 22.73 Not Reported Full recovery 14 days [19]
50M Kidney, 1992, 2016 MMF Tacrolimus MMF, Tacrolimus,ceftriaxone 26.22 3.2 60% Not Reported Not Reported Full recovery 13 days [17]
58M Kidney, 2017 Belatacept MMF Prednisone BelataceptCyclosporinePrednisoneMMF discontinued during treatment 29 5.04 16% 14 Not Reported Full recovery 18 days [20]
36F Kidney, 1993, 1995 Tacrolimus Prednisone Hydroxychloroquine, opinavir/ritonavir, ceftriaxone, tacrolimus, methlyprednisolone Within normal limits(reported elevated IL-8) High neutrophil normal 67 Not Reported Full recovery 9 days [21]
58M Kidney MMF Prednisone MethylprednisoloneMMF discontinued during treatment Not Reported Not Reported Not Reported Not Reported Not Reported Mechanical ventilation; death due to multi-organ failure on Day 40 40 days [22]
52 M Kidney Tacrolimus MMF Prednisone Imifovir, Moxifloxacin Methylprednisolone, Biapenem, interferon alphaAll immunosuppressive agents discontinued during treatment Day 2: 19.53 Day 2: 5.54; Day 11 11.68 Day 2: 17.9 % Day 11: 12 % Day 2: 54; Day 11: 1.4 Not Reported Full recovery 18 days [23]