IL-6 signal transduction occurs via three main pathways: classical signal transduction, trans signal transduction, and trans presentation [11]. The classical signal transduction involves IL-6 binding to the IL-6R and forming a complex; the IL6-IL6R complex then binds to membrane gp130 and subsequently initiates intracellular transduction [11]. The trans signal transduction pathway occurs with IL-6 binding to sIL-6R and forming a complex; the IL6-sIL6R complex then binds to membrane gp130, which then initiates intracellular signal transduction [11]. The trans presentation signal involves sgp130 forming a complex with sIL-6R to prevent sIL-6R from binding to membrane-bound gp130; the JAK-STATA, RAS-RAF, and ATK-PI3K pathways are then activated [11].