SARS-CoV-2 has created the wide spread fear of death. As the virus has newly emerged, there is no known drug or vacine, however, with all possible available knowledge and tools concerted efforts are being made to protect people from SARS-CoV-2. In order to develop effective and new treatment options, researchers are racing with their investigations and findings are exploding from all over the world. The search of full text journal articles of coronavirus during the last six months showed > 9000 documents in PubMed, which is an indicator of such a great effort of the scientific community at the time of tragedy. VirusDisease, an international journal is publishing articles on all aspect of virus disease research. During April 2020, we planned a special issue of VirusDisease on “The global emergence of coronavirus in human” and very soon numerous articles were submitted to the journal indicating a great interest and concern about the topic. The special issue of VirusDisease presents 20 articles including the article types of review, commentary, original article and short communication covering the subject areas on emergence of the disease, potential cases, transmission dynamics, diagnosis, pathogenesis, food safety and hygiene, therapeutic strategies and antiviral properties of Ayurveda products.