In the current COVID-19-pandemic, it is important to rule out an infection with COVID-19 in patients undergoing cardiac surgery to prevent complications from COVID-19 infection for a variety of reasons—for example, there is currently no available information on how these patients tolerate cardiopulmonary bypass. For this reason and to ensure the availability of intensive care unit (ICU) beds, most countries recommend postponing elective surgeries or interventions as much as possible. In our patient, the CT scan with interstitial infiltration was highly suspicious for a COVID-19 infection that was confirmed by three independent radiologists. In contrast, two consecutive PCR tests returned negative. Recently, it has been discussed that PCR testing might be inferior to CT scans to detect infections as the average time between initial negative and positive reverse transcription polymerase chain reaction test results in patients who already display signs of infection on CT scans is 5.1 ± 1.5 days [2].