F.-S.W., G.S., and J.-Y.Z. conceived, designed, and supervised experiments. J.-W.S., X.F., P.X., C.Z., and T.Y. collected clinical samples. W.-J.C., S.-Y.W., F.-P.M., Z.X., J.-L.F., and L.H. collected clinical information. J.-W.S., S.M.L., X.F., H.T., S.Z., R.W., and Z.W. performed the experiments. J.-W.S., W.-J.C., G.H.C., and B.L. performed the statistical analysis. J.-W.S., S.M.L., G.H.C., T.-J.J., M.S., F.-S.W., J.-Y.Z., and G.S. interpreted data. S.M.L. and J.-W.S. wrote the manuscript. All authors read and approved the final manuscript.