Spearman Correlation Analysis Spearman correlation between variables and clinical indicators were performed with data from COVID-19 patients. For each pair of variable and clinical indicator, samples with missing clinical data were omitted from the calculations. Correlation plots for all variables grouped by metabolite class were presented. Only correlations with p < 0.05 were indicated with colored circles. Negative correlations were shown in red and positive correlations were shown in blue, with sizes of circles representing the magnitude of the correlations.