Progressive increases with increasing disease severity were similarly noted for GM3s of varying acyl chain lengths, e.g., very long-chain GM3 d18:0/26:0 (p = 0.0008) and GM3 d18:1/24:1 (p = 0.0015), as well as medium-chain such as GM3 d18:1/16:0 (p = 0.0017) (Figure 5B).