PUFA-PE Accumulation Was Associated with Reductions in PSs in Mild COVID-19
Module I comprises PS 34:1 as the hub connected to numerous PUFA-PEs, i.e., PE 40:4(20:0/20:4) and PE 40:5(20:1/20:4), by green lines (+/0), indicating that the positive association between PS and PUFA-PEs in healthy controls was lost in mild COVID-19. PUFA-PEs were elevated while PSs were reduced in mild COVID-19 relative to controls (Figures 2 and S4). These suggest that PS synthase, which catalyzes the production of PSs from PEs (Han, 2016), may be compromised upon early infection, resulting in a loss of correlation between these lipids.