Among 23 patients who died, 18 (78.3%) cases had DD1 increased, 12 of 18 had DD1 two times higher (>1.10 mg/L), 22 cases had DD2 and DD3 increased, 21 of 22 had DD2 and DD3 two times higher (>1.10 mg/L). Eight cases in exacerbated patients occurred increased DD2 and DD3 all higher (1.10 mg/L) (Table 3).