Table 3  Correlation between the dynamics changes of DD, PT, APTT, Fg, and the prognosis of COVID-19.
Parameters  Outcome at composite endpoint (n)  Total
Hospital discharge  Improved  Exacerbation  Death
DD1 (M ± SD)  0.87 ± 1.73  1.55 ± 3.93  6.51 ± 10.29  3.47 ± 7.41  1.97 ± 5.01
 <0.55  38  18  4  5  65
 0.55-1.11  3  6  0  6  15
 >1.11  11  8  4  12  35
 Total  52  32  8  23  115
 χ2, P   χ 2 = 20.82   P < 0.01
 r, P   r = 0.346   P < 0.01
DD2 (M ± SD)  1.62 ± 2.29  4.73 ± 8.02  12.40 ± 13.21  8.08 ± 10.96  4.50 ± 7.99
 <0.55  20  5  0  1  26
 0.55-1.11  12  11  0  1  24
 >1.11  20  16  8  21  65
 Total  52  32  8  23  115
 χ2, P   χ 2 = 30.11   P < 0.01
 r, P   r = 0.439   P < 0.01
DD3 (M ± SD)  1.27 ± 2.08  2.38 ± 4.27  6.22 ± 3.75  8.93 ± 10.91  3.40 ± 6.23
 <0.55  26  11  0  2  39
 0.55-1.10  11  9  0  0  20
 >1.10  15  12  8  21  56
 Total  52  32  8  23  115
 χ2, P   χ 2 = 36.86   P < 0.01
 r, P   r = 0.467   P < 0.01
PT1 (M ± SD)  11.91 ± 0.99  12.56 ± 1.84  13.41 ± 2.37  13.86 ± 3.68  12.59 ± 2.21
 <9.2  0  0  0  0  0
 9.20-15.0  52  31  6  18  107
 >15  0  1  2  5  8
 Total  52  32  8  23  115
 χ2, P   χ 2 = 16.403   P < 0.01
 r, P   r = 0.331   P < 0.01
PT2 (M ± SD)  12.97 ± 2.29  13.74 ± 4.28  14.23 ± 2.13  16.63 ± 5.06  14.00 ± 3.80
 <9.2  0  0  0  0  0
 9.20-15.0  50  28  5  13  96
 >15  2  4  3  10  19
 Total  52  32  8  23  115
 χ2, P   χ 2 = 21.104   P < 0.01
 r, P   r = 0.399   P < 0.01
PT3 (s)  12.72 ± 1.68  12.81 ± 2.45  16.56 ± 5.50  24.52 ± 15.20  15.37 ± 8.45
 <9.2  0  0  0  0  0
 9.20-15.0  50  30  5  5  90
 >15  2  2  3  18  25
 Total  52  32  8  23  115
 χ2, P   χ 2 = 58.66   P < 0.01
 r, P   r = 0.595   P < 0.01
APTT1 (M ± SD)  36.55 ± 8.75  34.95 ± 9.51  32.09 ± 5.27  35.53 ± 10.54  35.59 ± 9.13
 <21.00  0  0  0  2  2
 21.00-37.00  27  21  7  11  66
 >37.00  25  11  1  10  47
 Total  52  32  8  23  115
 χ2, P   χ 2 = 12.884   P < 0.05
 r, P   r = −0.131   P > 0.05
APTT2 (M ± SD)  28.56 ± 6.48  27.79 ± 4.93  27.66 ± 3.42  32.98 ± 8.53  29.17 ± 6.63
 <21.00  1  1  0  0  2
 21.00-37.00  48  29  8  19  104
 >37.00  3  2  0  4  9
 Total  52  32  8  23  115
 χ2, P   χ 2 = 4.857   P > 0.05
 r, P   r = 0.122   P > 0.05
APTT3 (M ± SD)  28.78 ± 4.18  27.07 ± 3.38  29.44 ± 4.92  40.40 ± 13.80  30.67 ± 8.58
 <21.00  1  0  0  1  2
 21.00-37.00  48  32  7  10  97
 >37.00  3  0  1  12  16
 Total  52  32  8  23  115
 χ2, P   χ 2 = 38.632   P < 0.01
 r, P   r = 0.359   P < 0.01
TT1
 <10  0  0  1  0  1
 10-20  51  32  7  20  110
 >20  1  0  0  3  4
 Total  52  32  8  23  115
 χ2, P   χ 2 = 21.510   P < 0.01
 r, P   r = 0.225   P < 0.05
TT2
 <10  0  0  0  0  0
 10-20  52  31  8  20  111
 >20  0  1  0  3  4
 Total  52  32  8  23  115
 χ2, P   χ 2 = 8.442   P < 0.05
 r, P   r = 0.167   P > 0.05
TT3
 <10  0  0  0  0  0
 10-20  51  32  8  20  111
 >20  1  0  0  3  4
 Total  52  32  8  23  115
 χ2, P   χ 2 = 8.084   P < 0.05
 r, P   r = 0.136   P > 0.05
Fg1 (M ± SD)  4.49 ± 1.29  4.81 ± 1.31  5.30 ± 1.44  4.39 ± 2.00  4.61 ± 1.48
 <2.00  1  2  0  4  7
 2.00-4.00  19  8  1  6  34
 >4.00  32  22  7  13  74
 Total  52  32  8  23  115
 χ2, P   χ 2 = 9.81   P > 0.05
 r, P   r = −0.02   P > 0.05
Fg2 (M ± SD)  3.55 ± 1.31  3.86 ± 1.32  3.84 ± 1.45  3.24 ± 1.80  3.60 ± 1.43
 <2.00  3  1  1  8  13
 2.00-4.00  35  20  3  9  67
 >4.00  14  11  4  6  35
 Total  52  32  8  23  115
 χ2, P   χ 2 = 18.92   P < 0.01
 r, P   r = −0.09   P > 0.05
Fg3 (M ± SD)  3.11 ± 1.03  3.96 ± 1.42  4.13 ± 2.49  3.24 ± 1.44  3.43 ± 1.41
 <2.00  3  1  2  3  9
 2.00-4.00  42  19  3  15  79
 >4.00  7  12  3  5  27
 Total  52  32  8  23  115
 χ2, P   χ 2 = 13.28   P < 0.05
 r, P   r = 0.07   P > 0.05
Normal reference values: DD (<0.55 mg/L); PT (9.20-15 sec); APTT (21.00-37.00 sec); TT (10-20 sec); Fg (2.00-4.00 g/L). ∗P value was calculated by a 2-sided test.