PMC:7299399 / 31421-31843 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T139","span":{"begin":23,"end":34},"obj":"Body_part"},{"id":"T140","span":{"begin":92,"end":103},"obj":"Body_part"},{"id":"T141","span":{"begin":184,"end":186},"obj":"Body_part"},{"id":"T142","span":{"begin":214,"end":220},"obj":"Body_part"},{"id":"T143","span":{"begin":225,"end":236},"obj":"Body_part"},{"id":"T144","span":{"begin":225,"end":230},"obj":"Body_part"},{"id":"T145","span":{"begin":305,"end":316},"obj":"Body_part"},{"id":"T146","span":{"begin":305,"end":310},"obj":"Body_part"},{"id":"T147","span":{"begin":321,"end":327},"obj":"Body_part"},{"id":"T148","span":{"begin":328,"end":334},"obj":"Body_part"},{"id":"T149","span":{"begin":400,"end":411},"obj":"Body_part"}],"attributes":[{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma7196"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma5034"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma9671"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma7196"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A149","pred":"fma_id","subj":"T149","obj":"http://purl.org/sig/ont/fma/fma62863"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T33","span":{"begin":214,"end":220},"obj":"Body_part"},{"id":"T34","span":{"begin":225,"end":236},"obj":"Body_part"},{"id":"T35","span":{"begin":225,"end":230},"obj":"Body_part"},{"id":"T36","span":{"begin":305,"end":316},"obj":"Body_part"},{"id":"T37","span":{"begin":305,"end":310},"obj":"Body_part"},{"id":"T38","span":{"begin":321,"end":327},"obj":"Body_part"},{"id":"T39","span":{"begin":328,"end":334},"obj":"Body_part"}],"attributes":[{"id":"A33","pred":"uberon_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"A34","pred":"uberon_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0002391"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T117","span":{"begin":38,"end":46},"obj":"Disease"},{"id":"T118","span":{"begin":115,"end":123},"obj":"Disease"},{"id":"T119","span":{"begin":382,"end":390},"obj":"Disease"}],"attributes":[{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A118","pred":"mondo_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T287","span":{"begin":80,"end":84},"obj":"http://purl.obolibrary.org/obo/PR_000002064"},{"id":"T288","span":{"begin":214,"end":220},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"T289","span":{"begin":225,"end":236},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"T290","span":{"begin":305,"end":316},"obj":"http://purl.obolibrary.org/obo/UBERON_0000029"},{"id":"T291","span":{"begin":321,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T234","span":{"begin":140,"end":147},"obj":"Chemical"},{"id":"T235","span":{"begin":184,"end":186},"obj":"Chemical"}],"attributes":[{"id":"A234","pred":"chebi_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A236","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T41","span":{"begin":400,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0070227"},{"id":"T42","span":{"begin":412,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T43","span":{"begin":412,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0006915"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}

{"project":"LitCovid-sentences","denotations":[{"id":"T123","span":{"begin":0,"end":422},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}

{"project":"LitCovid-PubTator","denotations":[{"id":"505","span":{"begin":64,"end":68},"obj":"Gene"},{"id":"506","span":{"begin":80,"end":84},"obj":"Gene"},{"id":"507","span":{"begin":85,"end":90},"obj":"Gene"},{"id":"508","span":{"begin":184,"end":188},"obj":"Gene"},{"id":"512","span":{"begin":359,"end":367},"obj":"Species"},{"id":"517","span":{"begin":115,"end":125},"obj":"Species"},{"id":"520","span":{"begin":38,"end":46},"obj":"Disease"},{"id":"521","span":{"begin":205,"end":213},"obj":"Disease"},{"id":"522","span":{"begin":372,"end":376},"obj":"Disease"},{"id":"523","span":{"begin":382,"end":390},"obj":"Disease"}],"attributes":[{"id":"A505","pred":"tao:has_database_id","subj":"505","obj":"Gene:59272"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"Gene:968"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"Gene:6614"},{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"Gene:3569"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"Tax:9606"},{"id":"A517","pred":"tao:has_database_id","subj":"517","obj":"Tax:2697049"},{"id":"A520","pred":"tao:has_database_id","subj":"520","obj":"MESH:C000657245"},{"id":"A521","pred":"tao:has_database_id","subj":"521","obj":"MESH:D007239"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"MESH:D003643"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Concerning the role of macrophages in COVID-19, the presence of ACE2-expressing CD68+CD169+ macrophages containing SARS-CoV-2 nucleoprotein antigen and showing an increased release of IL-6 was observed in infected spleen and lymph nodes.100 Notably, immunohistochemical and immunofluorescence analyses of lymph nodes and spleen tissue from autopsy samples of patients who died from COVID-19 revealed lymphocytic apoptosis."}