etabolic changes in arachidonic acid with release of thromboxane A2 and secretion of IL-1β, IL-6, TNF-α, platelet activating factor & nitric oxide. In addition infection induces neutrophil activation, aggregation and degranulation with release of O2 radicals and proteases and CCR4+CCR6+Th17 cell activation with secretion of IL-2, IL-7, IFN-γ, G-